Structure of PDB 4gaa Chain A Binding Site BS01

Receptor Information
>4gaa Chain A (length=606) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADPSSFASPEKFNIKHMHLKLHVDFTSRAIAASTSLTVRSLQDSLASLIL
DTKDLTIKKVAVNGKDATFALGTTHSFKGTPLEITLPFSLTRGQEVIVEI
DSVTSPKSSALQWLNKEQTAGKIHPYLFSQCQATHCRSIIPCQDTPSVKF
TYYSQVSVPKELMALMSALRDGELSEQSDSNRKIYRFKQNVPIPSYLIAL
VVGALEGRKVGPRTTIWTEKELLEPSVYEFAETEKMLKYAEDLAGPYVWG
QYDLLILPPSFPYGGMENPCLTFVTPTVLAGDRSLASVIAHEISHSWTGN
LVTNETWENFWLNEGHTVYLERRIDGRLYGEEFRQFKALGGWKELQNSVN
TFGATNPLTNLVPNLHEVDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFL
GFLKSYIQMFAFKSVTTEEWKKFLYSYFKDKVDILDKVDWKGWMHTPGMP
PVQPKYDMTLANACITLGQKWVKATESDLGSFSADDVKDLSSHQLIEVLA
ILLLEKPLPVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAGWEDVIPLA
LAMATEQGRMKFTRPLYRDLYNFEKAREQTVNTFLKNRSFMHPVTEMLVA
KDLHIS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4gaa Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gaa Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		H292 H296 E315
Binding residue
(residue number reindexed from 1)		H291 H295 E314
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E268 H292 E293 H296 E315 D372 Y380
Catalytic site (residue number reindexed from 1) E267 H291 E292 H295 E314 D371 Y379
Enzyme Commision number 3.3.2.6: leukotriene-A4 hydrolase.
3.4.11.4: tripeptide aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004301 epoxide hydrolase activity
GO:0004463 leukotriene-A4 hydrolase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019370 leukotriene biosynthetic process
GO:0043171 peptide catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4gaa, PDBe:4gaa, PDBj:4gaa
PDBsum4gaa
PubMed24333438
UniProtQ6IP81|LKHA4_XENLA Leukotriene A-4 hydrolase (Gene Name=lta4h.L)

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