Structure of PDB 4g1w Chain A Binding Site BS01

Receptor Information
>4g1w Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGLTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGG
VLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFE
KLFPDVLFPLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSE
AEAPPREHTIEEWKELIYKEVM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4g1w Crystal structure of JNK1 in complex with JIP1 peptide and inhibitor
Resolution2.45 Å
Binding residue
(original residue number in PDB)		R127 S161 D162 C163 W324 E329
Binding residue
(residue number reindexed from 1)		R120 S154 D155 C156 W295 E300
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162 T166
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4g1w, PDBe:4g1w, PDBj:4g1w
PDBsum4g1w
PubMed
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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