Structure of PDB 4fz3 Chain A Binding Site BS01

Receptor Information
>4fz3 Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFLQQYDLPYPEAIFE
LPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNID
GLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCP
VCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLT
EAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTE
EMRDLVQRET
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fz3 Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate
Resolution2.1 Å
Binding residue
(original residue number in PDB)		F180 H248 V292 F294 G295 E296 P297 H305
Binding residue
(residue number reindexed from 1)		F49 H117 V161 F163 G164 E165 P166 H174
Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 F157 N229 D231 H248
Catalytic site (residue number reindexed from 1) P34 D35 F36 N98 D100 H117
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4fz3, PDBe:4fz3, PDBj:4fz3
PDBsum4fz3
PubMed23316803
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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