Structure of PDB 4ft4 Chain A Binding Site BS01

Receptor Information

>4ft4 Chain A (length=688) Species: 4577 (Zea mays)

HEPEFIGSPVAADEARSNWPKRYELKARCHYRSAKVDNVVYCLGDDVYVK
AGENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGHK
HDPRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYYD
MSYSVAYSTFANITRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWAV
DFNSFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYVEFVVEKLV
GICYGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEGH
KRKILPLPGDVDVICGGPPCQGISGFNRYRNRDEPLKDEKNKQMVTFMDI
VAYLKPKYVLMENVVDILKFADGYLGKYALSCLVAMKYQARLGMMVAGCY
GLPQFRMRVFLWGALSSMVLPKYPLPTYDVVVRGGAPNAFSQCMVAYDET
QKPSLKKALLLGDAISDLPKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKD
MLDWSFGEGAGPDEGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGV
RVGANNIVEWDPEIERVKLSSGKPLVPDYAMSFIKGKSLKPFGRLWWDET
VPTVVTRAEPHNQVIIHPTQARVLTIRENARLQGFPDYYRLFGPIKEKYI
QVGNAVAVPVARALGYCLGQAYLGESEGSDPLYQLPPS

Ligand information

>4ft4 Chain P (length=7) Species: 3702 (Arabidopsis thaliana)

QTARKST

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ft4 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): K195 Y203 W224 N258 N260
• Binding residue (residue number reindexed from 1): K50 Y58 W79 N113 N115

Enzymatic activity

• Catalytic site (original residue number in PDB): C517 E559 R603 R605
• Catalytic site (residue number reindexed from 1): C320 E362 R406 R408
• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003682 chromatin binding
• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:4ft4, PDBe:4ft4, PDBj:4ft4
• PDBsum: 4ft4
• PubMed: 23021223
• UniProt: Q9AXT8|CMT1_MAIZE DNA (cytosine-5)-methyltransferase 1 (Gene Name=MET2A)