Structure of PDB 4fr8 Chain A Binding Site BS01

Receptor Information
>4fr8 Chain A (length=493) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKE
DVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALET
LDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHE
PVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANL
IKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAA
GSSNLKRVTLQLGGKSPNIIMSDADMDWAVEQAHFALFFNQGQSCSAGSR
TFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYI
NTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQI
LKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYD
VFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
Ligand information
Ligand IDTNG
InChIInChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
InChIKeySNIOPGDIGTZGOP-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O
OpenEye OEToolkits 1.7.6C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
ACDLabs 12.01O=[N+]([O-])OC(CO[N+]([O-])=O)CO[N+](=O)[O-]
FormulaC3 H5 N3 O9
Namepropane-1,2,3-triyl trinitrate;
nitroglycerin
ChEMBLCHEMBL730
DrugBankDB00727
ZINCZINC000008214625
PDB chain4fr8 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fr8 Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F170 L173 W177 F296 S301 C302 D457 F459
Binding residue
(residue number reindexed from 1)		F163 L166 W170 F289 S294 C295 D450 F452
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N169 K192 Q268 C302 E399 E476
Catalytic site (residue number reindexed from 1) N162 K185 Q261 C295 E392 E469
Enzyme Commision number 1.2.1.3: aldehyde dehydrogenase (NAD(+)).
Gene Ontology
Molecular Function
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0008957 phenylacetaldehyde dehydrogenase (NAD+) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
GO:0106435 carboxylesterase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006066 alcohol metabolic process
GO:0006068 ethanol catabolic process
GO:0018937 nitroglycerin metabolic process
GO:0046185 aldehyde catabolic process
GO:1903179 regulation of dopamine biosynthetic process
GO:1905627 regulation of serotonin biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fr8, PDBe:4fr8, PDBj:4fr8
PDBsum4fr8
PubMed22988236
UniProtP05091|ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial (Gene Name=ALDH2)

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