Structure of PDB 4fo6 Chain A Binding Site BS01

Receptor Information
>4fo6 Chain A (length=315) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACS
IPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQM
WYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQK
AAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGGIFSRLLDSLRQEG
FLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSA
HFNRSMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPGRVLPTPTEKDVF
RLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB4fo6 The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Resolution2.007 Å
Binding residue
(original residue number in PDB)		W274 V462 K463 G464 T471 K472 R514 R517 K521 L527 S528 H530 H541
Binding residue
(residue number reindexed from 1)		W23 V207 K208 G209 T211 K212 R254 R257 K261 L267 S268 H270 H281
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D176 D178 D230
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4fo6, PDBe:4fo6, PDBj:4fo6
PDBsum4fo6
PubMed22584622
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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