Structure of PDB 4flu Chain A Binding Site BS01

Receptor Information
>4flu Chain A (length=758) Species: 29292 (Pyrococcus abyssi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HAGMIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSA
IDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIR
EKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYH
EGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKV
IREKDPDVIITYNGDNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDS
LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAE
AWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRS
STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGVKEPEKGLWE
GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGF
IPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYG
YAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIP
GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE
EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEK
LSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVI
GYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFG
YRKEDLKY
Ligand information
Receptor-Ligand Complex Structure
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PDB4flu Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D141 I142 E143 T144 Y146 N210 F214 F261 R265 T272 Y273 T274 D315 R612 R613 D614 E664 Q665 T667 R668 Y673 K674 H679
Binding residue
(residue number reindexed from 1)		D144 I145 E146 T147 Y149 N213 F217 F264 R268 T275 Y276 T277 D318 R613 R614 D615 E665 Q666 T668 R669 Y674 K675 H680
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4flu, PDBe:4flu, PDBj:4flu
PDBsum4flu
PubMed22902479
UniProtP0CL76|DPOL_PYRAY DNA polymerase 1 (Gene Name=polI)

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