Structure of PDB 4fjv Chain A Binding Site BS01

Receptor Information
>4fjv Chain A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNC
FYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNA
FYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFR
HFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDT
ALNHHVFPEAATPSVYLLYKTSHYNILYAAD
Ligand information
Ligand IDNEH
InChIInChI=1S/C2H7N/c1-2-3/h2-3H2,1H3
InChIKeyQUSNBJAOOMFDIB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCN
ACDLabs 10.04NCC
FormulaC2 H7 N
NameETHANAMINE
ChEMBLCHEMBL14449
DrugBank
ZINC
PDB chain4fjv Chain B Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fjv The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.
Resolution2.047 Å
Binding residue
(original residue number in PDB)		G49 C51
Binding residue
(residue number reindexed from 1)		G48 C50
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0006508 proteolysis
GO:0016579 protein deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:2000780 negative regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fjv, PDBe:4fjv, PDBj:4fjv
PDBsum4fjv
PubMed25590432
UniProtQ96DC9|OTUB2_HUMAN Ubiquitin thioesterase OTUB2 (Gene Name=OTUB2)

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