Structure of PDB 4ffb Chain A Binding Site BS01

Receptor Information
>4ffb Chain A (length=435) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MREVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPKGGEEGF
STFFHETGYGKFVPRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDA
ANNYARGHYTVGREILGDVLDRIRKLADQCDGLQGFLFTHSLGGGTGSGL
GSLLLEELSAEYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHAD
CTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLN
VDLNEFQTNLVPYPRIHFPLVSYSPVLSKSESNSVSEITNACFEPGNQMV
KCDPRDGKYMATCLLYRGDVVTRDVQRAVEQVKNKKTVQLVDWCPTGFKI
GICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRIDRKFDLMYAKRA
FVHWYVGEGMEEGEFTEAREDLAALERDYIEVGAD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4ffb Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ffb A TOG: alpha beta-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase.
Resolution2.882 Å
Binding residue
(original residue number in PDB)		Q11 E72
Binding residue
(residue number reindexed from 1)		Q11 E72
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000280 nuclear division
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0030473 nuclear migration along microtubule
GO:0045143 homologous chromosome segregation
GO:0098863 nuclear migration by microtubule mediated pushing forces
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0034399 nuclear periphery
GO:0045298 tubulin complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ffb, PDBe:4ffb, PDBj:4ffb
PDBsum4ffb
PubMed22904013
UniProtP09733|TBA1_YEAST Tubulin alpha-1 chain (Gene Name=TUB1)

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