Structure of PDB 4fdd Chain A Binding Site BS01

Receptor Information
>4fdd Chain A (length=836) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVL
TKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSP
LIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQK
ICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS
RTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHM
HNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVL
VNGMKYSDIDIILLKGSDWNLRKCSAAALDVLANVYRDELLPHILPLLKE
LLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALV
RSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAF
ATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGH
HLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPY
CEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEG
LGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKP
CIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQL
VEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNI
RDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFC
KILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Ligand information
>4fdd Chain B (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GPGKMDSRGEHRQDRRERPY
Receptor-Ligand Complex Structure
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PDB4fdd Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K377 A380 A381 D384 A423 W460 S502 T506 E509 D543 G546 D550 E588 S591 S592 D646 E653 D693 S723 N726 N727 T766 E769 N770
Binding residue
(residue number reindexed from 1)		K323 A326 A327 D330 A369 W406 S448 T452 E455 D489 G492 D496 E534 S537 S538 D592 E599 D639 S669 N672 N673 T712 E715 N716
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:4fdd, PDBe:4fdd, PDBj:4fdd
PDBsum4fdd
PubMed22778397
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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