Structure of PDB 4evh Chain A Binding Site BS01

Receptor Information
>4evh Chain A (length=294) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKVTDIANELKQAIDAKDEVQIAFIASEYSAESREKIAKAYVASYGKELP
DDIKKALKGGSEESLLMDLFSDRHEVRAQHIRDALSGRNDHMAFFDTVIL
CTPEDWHETVAAYTRMFKKPLVEDFMKDVGRKEDWCLLMEKWMAHERVSR
PGSPEDEAQRLDQAFDQKNTAYLIDFFGTVPSAEYRPIAEAFKAQNGKSI
EQAIATIYTKTDYYTFYCAHFALLGMHRLAAYLINCACNDKGDEKRMRRI
TGMMVDKCLGAKHAYKIYGDMGTDIERCFDKRMAPILRTLWRVK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4evh Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4evh Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K55 L58 K59 E64
Binding residue
(residue number reindexed from 1)		K54 L57 K58 E63
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007010 cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4evh, PDBe:4evh, PDBj:4evh
PDBsum4evh
PubMed22796298
UniProtP17063|GIA1_GIAIN Giardin subunit alpha-1

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