Structure of PDB 4eq0 Chain A Binding Site BS01

Receptor Information
>4eq0 Chain A (length=198) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQITLWKRPLVTIRIGGQLKEALLNTGSDFTVLEEMNLPGKWKPKMIRGI
GGFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QITLWKRPLVTIRIGGQLKEALLNTGSDDTVLEEMNLPGKWKPKMIGGIG
GFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNF
Ligand information
>4eq0 Chain P (length=7) Species: 11676 (Human immunodeficiency virus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ATIMMQR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4eq0 Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		R8 L23 N25 G27 S28 D29 F30 I47 R48 V82 I84 N125 G127 S128 D129 D130 P181
Binding residue
(residue number reindexed from 1)		R8 L23 N25 G27 S28 D29 F30 I47 R48 V82 I84 N124 G126 S127 D128 D129 P180
Enzymatic activity
Catalytic site (original residue number in PDB) N125 T126 G127
Catalytic site (residue number reindexed from 1) N124 T125 G126
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4eq0, PDBe:4eq0, PDBj:4eq0
PDBsum4eq0
PubMed22549928
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

[Back to BioLiP]