Structure of PDB 4ep2 Chain A Binding Site BS01

Receptor Information

>4ep2 Chain A (length=198) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIG
GFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNF

Ligand information

>4ep2 Chain B (length=7) Species: 11676 (Human immunodeficiency virus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AETFYVD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4ep2 Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	R8 N25 G27 A28 I47 G48 V82 R108 L123 N125 G127 D129 D130 I147 G148 P181 V182
Binding residue (residue number reindexed from 1)	R8 N25 G27 A28 I47 G48 V82 R107 L122 N124 G126 D128 D129 I146 G147 P180 V181

Enzymatic activity

Catalytic site (original residue number in PDB)	N125 T126 G127
Catalytic site (residue number reindexed from 1)	N124 T125 G126
Enzyme Commision number	2.7.7.- 2.7.7.49: RNA-directed DNA polymerase. 2.7.7.7: DNA-directed DNA polymerase. 3.1.-.- 3.1.13.2: exoribonuclease H. 3.1.26.13: retroviral ribonuclease H. 3.4.23.16: HIV-1 retropepsin.

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:4ep2, PDBe:4ep2, PDBj:4ep2
PDBsum	4ep2
PubMed	22549928
UniProt	P03369\|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

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