Structure of PDB 4efh Chain A Binding Site BS01

Receptor Information
>4efh Chain A (length=364) Species: 5755 (Acanthamoeba castellanii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPL
NPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVT
HTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVR
DIKEKLCYVALDFEQEMHTAASSSALEKSYELPDGQVITIGNERFRAPEA
LFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIA
DRMQKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKE
EYDESGPSIVHRKC
Ligand information
>4efh Chain B (length=20) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PSPREQLMESIRKGKELKQI
Receptor-Ligand Complex Structure
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PDB4efh Multiple Forms of Spire-Actin Complexes and their Functional Consequences.
Resolution2.48 Å
Binding residue
(original residue number in PDB)		G23 D24 D25 R28 Y143 G146 T148 E167 G168 S348 L349 T351
Binding residue
(residue number reindexed from 1)		G19 D20 D21 R24 Y133 G136 T138 E157 G158 S338 L339 T341
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006909 phagocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4efh, PDBe:4efh, PDBj:4efh
PDBsum4efh
PubMed22334675
UniProtP02578|ACT1_ACACA Actin-1

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