Structure of PDB 4eey Chain A Binding Site BS01

Receptor Information
>4eey Chain A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPTEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAA
IERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIR
KIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCR
GIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLT
KDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVI
KNMNTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4eey Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.
Resolution2.32 Å
Binding residue
(original residue number in PDB)		Q38 Y39 I48 S62 K86 R93 K293 R313 P316 K317 T318 G320 C321 S322 K323 N324
Binding residue
(residue number reindexed from 1)		Q37 Y38 I47 S61 K85 R92 K290 R310 P313 K314 T315 G317 C318 S319 K320 N321
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4eey, PDBe:4eey, PDBj:4eey
PDBsum4eey
PubMed22562137
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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