Structure of PDB 4eed Chain A Binding Site BS01

Receptor Information
>4eed Chain A (length=314) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFEIEVMNYSIEEFREFKTTDVESVLPFRDSSTPTWINITGIHRTDVVQR
VGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESE
QVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLID
ALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELAATI
WPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGL
LDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFGYPVVLAVMG
VIAVIMVVYFKKKK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4eed Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4eed Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.
Resolution3.92 Å
Binding residue
(original residue number in PDB)		D175 D179
Binding residue
(residue number reindexed from 1)		D150 D154
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0015087 cobalt ion transmembrane transporter activity
GO:0015095 magnesium ion transmembrane transporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
GO:0050897 cobalt ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006824 cobalt ion transport
GO:0015693 magnesium ion transport
GO:0030001 metal ion transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:1903830 magnesium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4eed, PDBe:4eed, PDBj:4eed
PDBsum4eed
PubMed23112165
UniProtQ9WZ31|CORA_THEMA Cobalt/magnesium transport protein CorA (Gene Name=corA)

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