Structure of PDB 4ecw Chain A Binding Site BS01

Receptor Information
>4ecw Chain A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEM
RAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQM
PIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYA
MCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEE
RLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAF
TVIKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4ecw Watching DNA polymerase eta make a phosphodiester bond
Resolution1.896 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 R61 S62 K86 R93 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 R64 S65 K89 R96 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ecw, PDBe:4ecw, PDBj:4ecw
PDBsum4ecw
PubMed22785315
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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