Structure of PDB 4ebb Chain A Binding Site BS01

Receptor Information
>4ebb Chain A (length=450) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGN
EGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTE
LLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPH
LVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQI
KDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYP
TDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYR
LYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDEL
RQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRR
NLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAAR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ebb Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ebb Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H451 E453
Binding residue
(residue number reindexed from 1)		H424 E426
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.14.2: dipeptidyl-peptidase II.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:1905146 lysosomal protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0035578 azurophil granule lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ebb, PDBe:4ebb, PDBj:4ebb
PDBsum4ebb
PubMed22952628
UniProtQ9UHL4|DPP2_HUMAN Dipeptidyl peptidase 2 (Gene Name=DPP7)

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