Structure of PDB 4e9d Chain A Binding Site BS01
Receptor Information
>4e9d Chain A (length=222) Species:
9606
(Homo sapiens) [
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HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYG
LGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSL
MKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAII
LHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGC
CKELASRLRYARTMVDKLLSSR
Ligand information
>4e9d Chain E (length=8) [
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DPPLHSTA
Receptor-Ligand Complex Structure
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PDB
4e9d
High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Resolution
2.75 Å
Binding residue
(original residue number in PDB)
W414 D416 Y417 Y421 Y481 F482 Y485 L490 L491 R516 H538 K540
Binding residue
(residue number reindexed from 1)
W42 D44 Y45 Y49 Y109 F110 Y113 L118 L119 R144 H166 K168
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4e9d
,
PDBe:4e9d
,
PDBj:4e9d
PDBsum
4e9d
PubMed
22730171
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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