Structure of PDB 4e7j Chain A Binding Site BS01

Receptor Information
>4e7j Chain A (length=365) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4e7j 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo.
Resolution3.1501 Å
Binding residue
(original residue number in PDB)		I112 L113 R114 P115 K124 E207 F208 S209 T210 Q215 S216 G218 K219 R222 D226 R229 S258 P259 N348 R350 T351
Binding residue
(residue number reindexed from 1)		I103 L104 R105 P106 K115 E198 F199 S200 T201 Q206 S207 G209 K210 R213 D217 R220 S249 P250 N339 R341 T342
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4e7j, PDBe:4e7j, PDBj:4e7j
PDBsum4e7j
PubMed22580823
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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