Structure of PDB 4e73 Chain A Binding Site BS01

Receptor Information
>4e73 Chain A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGLARYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGG
VLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFE
KLFPDVLFPKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEA
EREHTIEEWKELIYKEVM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4e73 Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		V118 M121 E126 R127 Y130 S161 D162 W324 E329
Binding residue
(residue number reindexed from 1)		V111 M114 E119 R120 Y123 S154 D155 W294 E299
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4e73, PDBe:4e73, PDBj:4e73
PDBsum4e73
PubMed24900545
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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