Structure of PDB 4e68 Chain A Binding Site BS01

Receptor Information
>4e68 Chain A (length=559) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDS
VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWK
RRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYK
GDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ
FTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVM
NMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE
VYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFT
KPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQI
TWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERE
RAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGSTQIQSVEPYTKQQ
LNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRAAPYLK
TKFICVTPF
Ligand information
Receptor-Ligand Complex Structure
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PDB4e68 Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.
Resolution2.585 Å
Binding residue
(original residue number in PDB)		R382 I431 V432 S465 Q469
Binding residue
(residue number reindexed from 1)		R238 I287 V288 S321 Q325
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4e68, PDBe:4e68, PDBj:4e68
PDBsum4e68
PubMed23434585
UniProtP42227|STAT3_MOUSE Signal transducer and activator of transcription 3 (Gene Name=Stat3)

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