Structure of PDB 4dzr Chain A Binding Site BS01

Receptor Information

>4dzr Chain A (length=163) Species: 521098 (Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446)

FEVGPDCLIPRPDTEVLVEEAIRFLKRMPSGTRVIDVGTGSGCIAVSIAL
ACPGVSVTAVDLSWAAADGIEWLIERAERGRPWHAIVSNPPYIPDGLQFY
RRMAALPPYVLARGRAGVFLEVGHNQADEVARLFAPWRERGFRVRKVKDL
RGIDRVIAVTREP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4dzr Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4dzr The crystal structure of protein-(glutamine-N5) methyltransferase (release factor-specific) from Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
• Resolution: 2.551 Å
• Binding residue (original residue number in PDB): D111 N206 E262
• Binding residue (residue number reindexed from 1): D13 N89 E121
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): L106 N206 P207
• Catalytic site (residue number reindexed from 1): L8 N89 P90
• Enzyme Commision number: 2.1.1.297: peptide chain release factor N(5)-glutamine methyltransferase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008168 methyltransferase activity
• GO:0008276 protein methyltransferase activity

Biological Process

• GO:0006479 protein methylation
• GO:0032259 methylation

External links

• PDB: RCSB:4dzr, PDBe:4dzr, PDBj:4dzr
• PDBsum: 4dzr
• UniProt: C8WUG7