Structure of PDB 4dyo Chain A Binding Site BS01

Receptor Information
>4dyo Chain A (length=457) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSELKETEKW
NIKPESKYFMTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRRS
RRSQVGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRLEQQLVH
VERPILRIPHLAIHLQRNINENFGPNTEMHLVPILATAIQEELEKGTERH
HSVLMSLLCAHLGLSPKDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNL
HSCFCALQALIDSCAGPGSLATEPHVRMVTLYDNEEVGSESAQGAQSLLT
ELVLRRISASCQHPTAFEEAIPKSFMISADMAHAVHPNYLDKHEENHRPL
FHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPLQDLMVRNDTPCGTT
IGPILASRLGLRVLDLGSPQLAMHSIREMACTTGVLQTLTLFKGFFELFP
SLAENLY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4dyo Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4dyo Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D264 E302 H440
Binding residue
(residue number reindexed from 1)		D248 E286 H424
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.21: aspartyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dyo, PDBe:4dyo, PDBj:4dyo
PDBsum4dyo
PubMed22720794
UniProtQ9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase (Gene Name=DNPEP)

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