Structure of PDB 4dwi Chain A Binding Site BS01

Receptor Information
>4dwi Chain A (length=581) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFF
LRPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLL
LAAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAE
HLVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKV
DTKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLP
VLKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVV
RPDTKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSES
DWLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSED
EVTPNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPG
VKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTP
IQGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLC
RLVPEVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
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PDB4dwi Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
Resolution1.85 Å
Binding residue
(original residue number in PDB)		N527 N529 K548 S585 T586 L610 T611 Q612 T613 S617 S618 T619 E620 N622 G711 Y714 G715 I716 S717 G720 L721 Q723 N724 R771 F786 R789 M790 N793 Q797
Binding residue
(residue number reindexed from 1)		N232 N234 K253 S290 T291 L315 T316 Q317 T318 S322 S323 T324 E325 N327 G416 Y419 G420 I421 S422 G425 L426 Q428 N429 R476 F491 R494 M495 N498 Q502
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004518 nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 DNA damage response
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dwi, PDBe:4dwi, PDBj:4dwi
PDBsum4dwi
PubMed
UniProtE1C9K5

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