Structure of PDB 4dqs Chain A Binding Site BS01

Receptor Information
>4dqs Chain A (length=573) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLR
PETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLA
AYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHL
VRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDT
KRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVL
YSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPDTKKVH
TIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWLIFAAD
YSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVTPNMRR
QAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKRYMENI
VQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQGSAADI
IKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCRLVPEVME
QAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4dqs Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
Resolution1.66 Å
Binding residue
(original residue number in PDB)		A433 T556 S557 A558 R578 K582 Y587 R615 Q624 N625 I626 P627 I628 R629 H829 D830
Binding residue
(residue number reindexed from 1)		A136 T253 S254 A255 R275 K279 Y284 R312 Q321 N322 I323 P324 I325 R326 H526 D527
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4dqs, PDBe:4dqs, PDBj:4dqs
PDBsum4dqs
PubMed22648417
UniProtQ5KWC1

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