Structure of PDB 4dm8 Chain A Binding Site BS01

Receptor Information
>4dm8 Chain A (length=238) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLW
DKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICT
RYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTE
TGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPPHMFPKI
LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
Ligand information
Receptor-Ligand Complex Structure
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PDB4dm8 Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K246 I260 L411 E414
Binding residue
(residue number reindexed from 1)		K69 I83 L232 E235
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dm8, PDBe:4dm8, PDBj:4dm8
PDBsum4dm8
PubMed22355136
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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