Structure of PDB 4dm6 Chain A Binding Site BS01

Receptor Information
>4dm6 Chain A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLW
DKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICT
RYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTE
TGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFP
KILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
Ligand information
Receptor-Ligand Complex Structure
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PDB4dm6 Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		K246 Q259 I260 K264 P410 L411 E414 M415 E417
Binding residue
(residue number reindexed from 1)		K69 Q82 I83 K87 P233 L234 E237 M238 E240
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dm6, PDBe:4dm6, PDBj:4dm6
PDBsum4dm6
PubMed22355136
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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