Structure of PDB 4dl5 Chain A Binding Site BS01

Receptor Information
>4dl5 Chain A (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4dl5 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Resolution2.92 Å
Binding residue
(original residue number in PDB)		Q38 Y39 K86 R93 K293 R313 K317 T318 G320 S322 K323 N324 R351
Binding residue
(residue number reindexed from 1)		Q37 Y38 K85 R92 K288 R308 K312 T313 G315 S317 K318 N319 R346
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4dl5, PDBe:4dl5, PDBj:4dl5
PDBsum4dl5
PubMed22529383
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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