Structure of PDB 4dl2 Chain A Binding Site BS01

Receptor Information
>4dl2 Chain A (length=428) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIK
NCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4dl2 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Resolution2.15 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 I48 S62 K86 R93 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Q37 Y38 W41 I47 S61 K85 R92 P312 K313 T314 G316 C317 S318 K319 N320 P322 R347
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4dl2, PDBe:4dl2, PDBj:4dl2
PDBsum4dl2
PubMed22529383
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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