Structure of PDB 4djs Chain A Binding Site BS01

Receptor Information
>4djs Chain A (length=507) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSA
IVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSP
VDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAIT
TDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVL
SVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEG
MEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEAL
VRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKL
LHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDT
QRVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIE
NIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAV
LFRMSED
Ligand information
Receptor-Ligand Complex Structure
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PDB4djs Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin.
Resolution3.029 Å
Binding residue
(original residue number in PDB)		H219 H223 S250 F253 T257 N261 N290 K292 D299 K335
Binding residue
(residue number reindexed from 1)		H72 H76 S103 F106 T110 N114 N143 K145 D152 K188
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0045296 cadherin binding
Biological Process
GO:0007155 cell adhesion

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Molecular Function
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Biological Process
External links
PDB RCSB:4djs, PDBe:4djs, PDBj:4djs
PDBsum4djs
PubMed23071338
UniProtP35222|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)

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