Structure of PDB 4dcj Chain A Binding Site BS01

Receptor Information
>4dcj Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKY
EVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP
VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTEDDCGIET
Ligand information
Receptor-Ligand Complex Structure
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PDB4dcj Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Resolution1.7 Å
Binding residue
(original residue number in PDB)		R64 H121 Q161 C163
Binding residue
(residue number reindexed from 1)		R31 H88 Q128 C130
Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) T29 S30 H88 G89 C130 R131
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dcj, PDBe:4dcj, PDBj:4dcj
PDBsum4dcj
PubMed22304005
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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