Structure of PDB 4da4 Chain A Binding Site BS01

Receptor Information

>4da4 Chain A (length=834) Species: 10090 (Mus musculus)

DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGEDGKTYFFQLWYNQEYARFESPPKTQPTED
NKHKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGD
SVYLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDA
PEPYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTD
INMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEA
YNSKTKNFEDPPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISET
LWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQ
KGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFF
LLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRA
IILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFR
TITVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHI
CKDMSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVK
NGYSSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLY
GRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYR
FFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLS

Ligand information

>4da4 Chain C (length=12)

gaggccgcctgc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4da4 Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): G1234 N1236 R1237 R1492 C1501 H1504 T1505 R1508 H1509 W1512 M1535 K1537
• Binding residue (residue number reindexed from 1): G468 N470 R471 R726 C735 H738 T739 R742 H743 W746 M769 K771

Enzymatic activity

• Catalytic site (original residue number in PDB): C1229 E1269 R1313 R1315
• Catalytic site (residue number reindexed from 1): C463 E503 R547 R549
• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003682 chromatin binding
• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:4da4, PDBe:4da4, PDBj:4da4
• PDBsum: 4da4
• PubMed: 22323818
• UniProt: P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)