Structure of PDB 4d5y Chain A Binding Site BS01 |
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| >4d5y Chain 2 (length=3616)
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cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggggcgcgggacaugug
gcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccu
ucugaucgaggcccagcccguggacggugugaggccgguagcggccggcg
cgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauaguca
acaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaag
agggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcc
cggaggauucaacccggcggcggguccggccgugucggcggcccggcgga
ucuuucccgcgcgggggaccgucccccggaccggcgaccggccgccgccg
ggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaag
gcccggcggggaagguggcucgggggcccccgaguguuacagcccccccg
gcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccg
cgcucuccccccucccggccccccggggggggccgggccaccccucccac
ggcgcgaccgcucucccaccccuccucccgggucggggggcggggcggac
uguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguu
cucucggggccacgcgcgcgucccccgggggacggcggagcgagcgcacg
gggucggcggcgacgucggcuacccacccgacccgucuugaaacacggac
caaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccgu
ggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggauccc
gaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccg
cgccggggagguggagcacgagcgcacguguuaggacccgaaagauggug
aacuaugccugggcagggcgaagccagaggaaacucugguggagguccgu
agcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaa
gacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucagga
uagcuggcgcuccaguuuuauccgguaaagcgaaugauuagaggucuugg
ggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagccc
ggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacu
uuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaagg
cgcccgaugccgacgcucaucagaccccagaaaagguguugguugauaua
gacagcacugccgaaucaacuagcccugaaaauggauggcgcuggagcgu
cgggcccauacccggccgucgccggcgccgcgacgaguaggagggccgcu
gcggugagccuugaagccuagggcgcgggcccggguggaggccgccgcag
gugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggc
cgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucg
guccugagagaugggcgagcgccguuccgaagggacgggcgauggccucc
guugcccucggccgaucgaaagggagucggguucagauccccgaauccgg
aguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgau
cccggagaagccggcgggagccccggggagaguucucuuuucuuugugaa
gggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuu
ggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuug
aaaauccgggggagaggguguaaaucucgcgccgggccguacccauaucc
gcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagg
uaagggaagucggcaagccggauccguaacuucgggauaaggauuggcuc
uaagggcugggugcagccgacuuagaacuggugcggaccaggggaauccg
acuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacg
cgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaau
gaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaa
augccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucc
cacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuu
ggcggaaucagcggggaaagaagacccuguugagcuugacucuagucugg
cacggugaagagacaugagagguguagaauaagugggaggcccgggccgc
cggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgg
gggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggc
cgggcgcgacccgcuccggggacagugccagguggggaguuugacugggg
cgguacaccugucaaacgguaacgcagguguccuaaggcgagcucaggga
ggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuuga
uuuucaguacgaauacagaccgugaaagcggggccucacgauccuucuga
ccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaac
uggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucg
augucggcucuuccuaucauugugaagcagaauucgccaagcguuggauu
guucacccacuaauagggaacgugagcuggguuuagaccgucgugagaca
gguuaguuuuacccuacugaugauguguuguugccaugguaauccugcuc
aguacgagaggaaccgcagguucagacauuugguguaugugcuuggcuga
ggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccuc
uaagucagaaucccgcccaggcgaacgauacggcagcgccgcggagccuc
gguuggccucggauagccggucccccgccuguccccgccggcgccgcgcg
ccgggaccgggguccggugcggagugcccuucguccugggaaacggggcg
cggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucgug
gggaaccuggcgcuaaaccauucguagacgaccugcuucugggucggggu
uucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcc
cucgacacaaggguuu |
.........................<<<<<<.....<<....>>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..[[[..<.......<..<<....<.....>....>>..>....
...>..<<<<<<<<.......<<.<<<.<<<.......<<<<.....<<<
<......>>>>.....((......<<<.....))>>>.....>>>>>>>>
>>>>....>>>>>>>>.......<<<<<<<........>>>>>>>.....
(((((..<<<<<<)))))..]]]...........................
.......<<....>>................<.......>..........
..........................<<<<<<<<..<<<......<<<<<
.<<<<.........<<<<<<<......<<<<..<<<<.<<<.<<<<.<<<
<.<<<<<<<<>>>>>>>>..>>>>.>>>>.>>>.>>>>.>>>>>>>>>>>
.......>>>>.>>>>>..<<<<<.<<..<<<<<<<.<..<<<.<.....
....<<.<<<.....<<.<<<<<<<..>>>>>>>...>>....>>>.>>.
..........>.>>>.....>>>>>>>>..............<<.<<<..
<<<<.....<<....<<<<<<<<<..>>>>>>>>>...<.<<<<<.<<<<
<<<<<<<<<<.<........<<<.<.<<..>>..>>>>...<<<<<<.<<
<......>>>.>>>>>>.>.>.>>>>>>>>>>>.>>....>>>>>.>...
......>>......<<<.<<<<<<<..>>>>>>>>>>.>>>>.>>>..>>
...>>..>>>>>....>>>...>>>>>>>>..<<<<........>>>><<
<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....
>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<<
..<<<...........>>>..>>>>..>>>>>.<<<<<<<<<.<<<....
....>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.
....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>..
.<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.....
..>>......>>>>>>......>.>>..<<<<<<......<<<....>>>
..<<.<<<<<<.<<.<<<<<<<<....<<<....<<<....<<<..<<<<
.<.........>.>>>>>>>....>>>..>.>>....>>>>>>....<<<
<<<<<.........>>>>>>>>....>>>>..>>>>>>..>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<
<(((.......<<<<<......<..........<<<.<<<<<<<<<....
....<<...>>....>>>>>>>>>>>>..........))).>....>>>>
>..>>>...>>>>>>><<<<<<.<...>.>>>>>>....>>>>>>...<<
<<<<<..<<......<<<<.<<<<....>>>>>>>>....>>.>>>>>>>
........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<
<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<
<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>
>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<
..<<.......<<<<<<<<....>>>>>>>>..<<<....>>>......<
<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....
<<<<..<<<.<<<<.....<<<.....>>>.....>>>>>>>...>>>>.
.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.....
....>>>>>>>................>>..>>>>>>>>..>>.....<<
......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<
<<.<<...............<<<<<...............>>>>><<.<<
<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<
..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>
>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>..
...>>>.>>>>..>>>>>.<<<<.........>>>>.........<....
.......<<<<<.......>>>>>.....>.....>>....>>.>>>>>>
>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>
>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<
<<<.<<<<<..<<<.<.<<<<..........<<<<<..<<<<..>>>>..
..........>>>>>.>>>>.>..>>>..>>>>>...<<<<<......<<
<.....<<<.<.....>.>>>................<<<<<<<......
>>>>>>>..>>>...>>>>>....>>>>>>>>>..>>>>>....<<....
.>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<
<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<
<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((.
.(((..>>>>>>.)))))))))..........]]]]...}]]]]......
.<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>....
...<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<...
......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.
>>>>....}}..}}}.]]]]].....<<<<<<....<<<....<<<<<..
...............>>>>>..<<<<....<<<<....<<.<<<<<<.}}
}..>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<.........
..>>>>>...>>>>..>>>....>>>>>>.....<<<<<<<.<<..<<<.
<...<<<.........<<<<.<<<....<<.....<<<<<<..>>>.>>>
..>>.....>>>.>>>>........>>>...<<<..<<<.....<<<<.<
<<<<<<......>>>>>>>>>>>....>>>..>>>.............>.
>>>..>>>>>>>>>.<<<<.....................<.<<<<<<<.
<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>
>>.>>>.>..>>.>>. |
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| PDB | 4d5y Cryo-Em Structures of Ribosomal 80S Complexes with Termination Factors and Cricket Paralysis Virus Ires Reveal the Ires in the Translocated State |
| Resolution | 9.0 Å |
Binding residue
(original residue number in PDB) | G2 R3 R6 Q8 R9 K10 G11 S14 A18 H19 V20 K21 H22 R23 G25 A26 F34 R37 Y40 I44 P52 R54 R64 Y67 R68 F69 T84 G85 F87 Y89 K93 Q95 N97 E118 K119 K125 L126 A127 R128 S130 N132 L150 P151 S152 K156 G172 G173 R174 I175 K177 I179 L180 K181 A182 Y186 H187 R193 N194 W196 R198 V199 R200 G201 V202 M204 N205 P206 V207 E208 H209 F211 G213 G214 N215 H216 H218 G220 K221 P222 S223 T224 R226 R227 D228 P230 A231 G232 R233 K234 V235 G236 L237 I238 A239 A240 R241 T243 G244 R245 L246 |
Binding residue
(residue number reindexed from 1) | G1 R2 R5 Q7 R8 K9 G10 S13 A17 H18 V19 K20 H21 R22 G24 A25 F33 R36 Y39 I43 P51 R53 R63 Y66 R67 F68 T83 G84 F86 Y88 K92 Q94 N96 E117 K118 K124 L125 A126 R127 S129 N131 L149 P150 S151 K155 G171 G172 R173 I174 K176 I178 L179 K180 A181 Y185 H186 R192 N193 W195 R197 V198 R199 G200 V201 M203 N204 P205 V206 E207 H208 F210 G212 G213 N214 H215 H217 G219 K220 P221 S222 T223 R225 R226 D227 P229 A230 G231 R232 K233 V234 G235 L236 I237 A238 A239 R240 T242 G243 R244 L245 |
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| Enzyme Commision number |
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