Structure of PDB 4cxh Chain A Binding Site BS01

Receptor Information
>4cxh Chain A (length=427) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHMNLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESF
KFAWILDKMKEERERGITIDLTFMKFETKKYVFTIIDAPGHRDFVKNMIT
GASQADAAILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQIIVAVNK
MDAPDVNYDQKRYEFVVSVLKKFMKGLGYQVDKIPFIPVSAWKGDNLIER
SPNMPWYNGPTLVEALDQLQPPAKPVDKPLRIPVQNVYSIPGAGTVPVGR
VETGVLRVGDKVVFMPPGVVGEVRSIEMHYQQLQQAEPGDNIGFAVRGVS
KSDIKRGDVAGHLDKPPTVAEEFEARIFVIWHPSAITVGYTPVIHVHTAS
VSSRIIEIKAKLDPKTGQVVEQNPQFLKAGDAAIVRFKPVKPLVVEKFSE
IPQLGRFAMRDMNRTVGIGIVTDVKPA
Ligand information
>4cxh Chain Y (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcggauuuagcucaguugggagagcgccggucuccaaaaccggagguccu
guguucgauccacagaauucgcacca
.<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>.....
Receptor-Ligand Complex Structure
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PDB4cxh Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement.
Resolution8.9 Å
Binding residue
(original residue number in PDB)		K63 Y241 S242 I243 P244 A246 G247 V249 A298 H335 P336 S337 Y343 S355 D414 M415 N416
Binding residue
(residue number reindexed from 1)		K60 Y238 S239 I240 P241 A243 G244 V246 A295 H332 P333 S334 Y340 S352 D411 M412 N413
Enzymatic activity
Catalytic site (original residue number in PDB) K19 S20 T71 H94
Catalytic site (residue number reindexed from 1) K16 S17 T68 H91
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cxh, PDBe:4cxh, PDBj:4cxh
PDBsum4cxh
PubMed24995983
UniProtQ9YAV0|EF1A_AERPE Elongation factor 1-alpha (Gene Name=tuf)

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