Structure of PDB 4cvh Chain A Binding Site BS01

Receptor Information
>4cvh Chain A (length=391) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMHPQAVAAVLPAGPTPKQFCPILERPLISYTLQALERVCWIKDIVVAVT
GENMEVMKSIIQKYQHKRISLVEAGVTRHRSIFNGLKALAEDQINSKLSK
PEVVIIHDAVRPFVEEGVLLKVVTAAKEHGAAGAIRPLVSTVVSPSADGC
LDYSLERARHRASEMPQAFLFDVIYEAYQQCSDYDLEFGTECLQLALKYC
CTKAKLVEGSPDLWKVTYKRDLYAAESIIKERISQEICVVMDTEEDNKHV
GHLLEEVLKSELNHVKVTSEALDQCYNFVCVNVTTSDFQETQKLLSMLEE
SSLCILYPVVVVSVHFLDFKLVPPSQKMENLMQIREFAKEVKERNILLYG
LLISYPQDDQKLQESLRQGAIIIASLIKERNSGLIGQLLIA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4cvh Chain A Residue 1452 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4cvh Human Ispd is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Resolution2.39 Å
Binding residue
(original residue number in PDB)		R126 H127
Binding residue
(residue number reindexed from 1)		R78 H79
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.40: D-ribitol-5-phosphate cytidylyltransferase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016779 nucleotidyltransferase activity
GO:0042803 protein homodimerization activity
GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0007411 axon guidance
GO:0008299 isoprenoid biosynthetic process
GO:0035269 protein O-linked mannosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cvh, PDBe:4cvh, PDBj:4cvh
PDBsum4cvh
PubMed26687144
UniProtA4D126|ISPD_HUMAN D-ribitol-5-phosphate cytidylyltransferase (Gene Name=CRPPA)

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