Structure of PDB 4cuf Chain A Binding Site BS01

Receptor Information
>4cuf Chain A (length=121) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPC
QNDASCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINE
FQCECPTGFTGHLCQVDLHHI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4cuf Chain A Residue 1531 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4cuf Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		D452 V453 E455 D469 Q470
Binding residue
(residue number reindexed from 1)		D41 V42 E44 D58 Q59
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4cuf, PDBe:4cuf, PDBj:4cuf
PDBsum4cuf
PubMed24803430
UniProtP46531|NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (Gene Name=NOTCH1)

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