Structure of PDB 4cqo Chain A Binding Site BS01

Receptor Information
>4cqo Chain A (length=510) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKT
DDLITRFFRLCTEMCVEISYRAQAEPTMIRAKCYHNLDAFVRLIALLVKH
SGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLL
ELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIA
RMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVTKPMQILYKGTLRVLLV
LLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLK
VDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQ
VSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIF
QNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQ
EQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEK
LFQSVAQCCM
Ligand information
Receptor-Ligand Complex Structure
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PDB4cqo Structural Basis for the Nanos-Mediated Recruitment of the Ccr4-not Complex and Translational Repression
Resolution2.8 Å
Binding residue
(original residue number in PDB)		K2331 W2338 F2353 Q2354 A2357 M2361
Binding residue
(residue number reindexed from 1)		K480 W487 F502 Q503 A506 M510
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0017148 negative regulation of translation
Cellular Component
GO:0030015 CCR4-NOT core complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4cqo, PDBe:4cqo, PDBj:4cqo
PDBsum4cqo
PubMed24736845
UniProtA5YKK6|CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (Gene Name=CNOT1)

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