Structure of PDB 4cn7 Chain A Binding Site BS01

Receptor Information
>4cn7 Chain A (length=79) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4cn7 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		K145 H146 Y147 K156 K160 R202
Binding residue
(residue number reindexed from 1)		K20 H21 Y22 K31 K35 R77
Binding affinityPDBbind-CN: Kd=155nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn7, PDBe:4cn7, PDBj:4cn7
PDBsum4cn7
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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