Structure of PDB 4cfh Chain A Binding Site BS01

Receptor Information

>4cfh Chain A (length=402) Species: 10116 (Rattus norvegicus)

RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVG
KIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG
LSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLC
GTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI
KDIREHEWFKQDLPKYLFPEDAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRAAKWHLGIRSQSRPNDIMAEVCRAIK
QLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDD
EI

Ligand information

>4cfh Chain C (length=21) Species: 10116 (Rattus norvegicus)

PGSHTIEFFEMCANLIKILAQ

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4cfh Structure of Mammalian Ampk and its Regulation by Adp
• Resolution: 3.24 Å
• Binding residue (original residue number in PDB): R415 A416 Q419 Y422 R436 S445 M447 R464 S465
• Binding residue (residue number reindexed from 1): R347 A348 Q351 Y354 R368 S377 M379 R396 S397

Enzymatic activity

• Catalytic site (original residue number in PDB): D139 K141 E143 N144 D157 S176
• Catalytic site (residue number reindexed from 1): D130 K132 E134 N135 D148 S167
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.11.26: [tau protein] kinase.
  2.7.11.31: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4cfh, PDBe:4cfh, PDBj:4cfh
• PDBsum: 4cfh
• PubMed: 21399626
• UniProt: P54645|AAPK1_RAT 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Gene Name=Prkaa1)