Structure of PDB 4cei Chain A Binding Site BS01

Receptor Information
>4cei Chain A (length=1170) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERMIRKITAEENP
IDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLNRA
SISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEY
AKGEKAFFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHL
YDVSEKSAIEELPFYQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRA
DNFLDDLAQIDELIQHQDDFSELYKRVPAVSFKRAKAVKGDEFDPALLDE
ATDLRNGAKKLLEKLKTDYFTRSPEQHLKSLAEMKPVIETLVQLVISYGK
RFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSEAARFYQEQFHEV
LVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAEPLLF
LSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVD
YDEQAELKLGAAYPDNDETETELLLIDNAEELETVQFEAKAIAKEIRKLI
SSPFKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANL
TSGYFEAVEVAVALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRL
ENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAFSKNHSVSEL
IWEVYRDTKYMDYVGGMPGGKQRQANLRVLYDRARQYESTAFRGLFRFLR
FIERMQERGDDLGTARGLSEQEDVVRLMTIHSSKGLEFPVVFVAGLGRNF
NMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMRRELLSEE
LRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQA
RTYLDFIGPALARHRDLHADISGHPARFAVQMIHSYDLLEKSERLEAIRR
GEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEILYRRPAFMMKK
GLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHRLYEKELLTEEQKDAI
DIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAHEADEPLL
VQGIIDCLYETEDGLYLLAYKSDRIEAAPILKKRYETQIQLYTKAVEQIA
KTKVKGCALYFFDGGHILTL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4cei Structural Basis for Translocation by Addab Helicase-Nuclease and its Arrest at Chi Sites.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		F65 N67 T108 H110 S111 I132 Q135 R288 A289 K290 F368 Y444 F446 R590 S591 H794 N812 N814 R914
Binding residue
(residue number reindexed from 1)		F61 N63 T104 H106 S107 I128 Q131 R284 A285 K286 F364 Y440 F442 R577 S578 H781 N799 N801 R901
Enzymatic activity
Catalytic site (original residue number in PDB) K36 T37 D407 E408 Q441 R873
Catalytic site (residue number reindexed from 1) K32 T33 D403 E404 Q437 R860
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003690 double-stranded DNA binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005829 cytosol
GO:0033202 DNA helicase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cei, PDBe:4cei, PDBj:4cei
PDBsum4cei
PubMed24670664
UniProtP23478|ADDA_BACSU ATP-dependent helicase/nuclease subunit A (Gene Name=addA)

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