Structure of PDB 4cco Chain A Binding Site BS01
Receptor Information
>4cco Chain A (length=458) Species:
9606
(Homo sapiens) [
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MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRAPTEELALTCSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
GEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEEP
KCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGLL
LTKMPLAL
Ligand information
>4cco Chain C (length=12) Species:
9606
(Homo sapiens) [
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GGCNHQHIGKPS
Receptor-Ligand Complex Structure
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PDB
4cco
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
R297 L299 M322 G324 N326 Y328 H340 D342 C373 S374 P375 S421 Q424 Y577
Binding residue
(residue number reindexed from 1)
R116 L118 M141 G143 N145 Y147 H159 D161 C192 S193 P194 S240 Q243 Y395
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79
: protein-L-histidine (3S)-3-hydroxylase.
External links
PDB
RCSB:4cco
,
PDBe:4cco
,
PDBj:4cco
PDBsum
4cco
PubMed
24814345
UniProt
Q9H6W3
|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)
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