Structure of PDB 4ccn Chain A Binding Site BS01
Receptor Information
>4ccn Chain A (length=458) Species:
9606
(Homo sapiens) [
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MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLCSPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRAPTEELALTSSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
GEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEEP
KCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGLL
LTKMPLAL
Ligand information
>4ccn Chain C (length=10) Species:
9606
(Homo sapiens) [
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GGNHQHICKP
Receptor-Ligand Complex Structure
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PDB
4ccn
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution
2.23 Å
Binding residue
(original residue number in PDB)
R272 T274 R297 C299 S300 M322 N326 Y328 F337 H340 D342 T419 S421 Q424 Y577
Binding residue
(residue number reindexed from 1)
R91 T93 R116 C118 S119 M141 N145 Y147 F156 H159 D161 T238 S240 Q243 Y395
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79
: protein-L-histidine (3S)-3-hydroxylase.
External links
PDB
RCSB:4ccn
,
PDBe:4ccn
,
PDBj:4ccn
PDBsum
4ccn
PubMed
24814345
UniProt
Q9H6W3
|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)
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