Structure of PDB 4ccm Chain A Binding Site BS01
Receptor Information
>4ccm Chain A (length=457) Species:
9606
(Homo sapiens) [
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MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRVPTEELALTSSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
GEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEEP
KCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGLL
LTKMPLA
Ligand information
>4ccm Chain C (length=8) Species:
9606
(Homo sapiens) [
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NHQHICKP
Receptor-Ligand Complex Structure
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PDB
4ccm
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution
2.51 Å
Binding residue
(original residue number in PDB)
R297 C300 M322 G324 N326 Y328 H340 T419 S421 T422 Q424 V576 Y577
Binding residue
(residue number reindexed from 1)
R116 C119 M141 G143 N145 Y147 H159 T238 S240 T241 Q243 V394 Y395
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79
: protein-L-histidine (3S)-3-hydroxylase.
External links
PDB
RCSB:4ccm
,
PDBe:4ccm
,
PDBj:4ccm
PDBsum
4ccm
PubMed
24814345
UniProt
Q9H6W3
|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)
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