Structure of PDB 4ccl Chain A Binding Site BS01

Receptor Information

>4ccl Chain A (length=371) Species: 562 (Escherichia coli)

MEYQLTLNWPDFLERHWQKRPVVLKRGFNNFIDPISPDELAGLAMESEVD
SRLVSHQDGKWQVSHGPFESYDHLGETNWSLLVQAVNHWHEPTAALMRPF
RELPDWRIDDLMISFSVPGGGVGPHLDQYDVFIIQGTGRRRWRVGEKLQK
QHCPHPDLLQVDPFEAIIDEELEPGDILYIPPGFPHEGYALENAMNYSVG
FRAPNTRELISGFADYVLQRELGGNYYSDPDVPPRAHPADVLPQEMDKLR
EMMLELINQPEHFKQWFGEFISQSRHELDIAPPEPPYQPDEIYDALKQGE
VLVRLGGLRVLRIGDDVYANGEKIDSPHRPALDALASNIALTAENFGDAL
EDPSFLAMLAALVNSGYWFFE

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4ccl Chain A Residue 1373

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ccl Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
• Resolution: 2.596 Å
• Binding residue (original residue number in PDB): H125 D127 H187
• Binding residue (residue number reindexed from 1): H125 D127 H186
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.14.11.47: [50S ribosomal protein L16]-arginine 3-hydroxylase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008198 ferrous iron binding
• GO:0016706 2-oxoglutarate-dependent dioxygenase activity
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0043687 post-translational protein modification

External links

• PDB: RCSB:4ccl, PDBe:4ccl, PDBj:4ccl
• PDBsum: 4ccl
• PubMed: 24814345
• UniProt: P27431|ROXA_ECOLI Ribosomal protein uL16 3-hydroxylase (Gene Name=roxA)