Structure of PDB 4c9d Chain A Binding Site BS01

Receptor Information
>4c9d Chain A (length=262) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPQAVVLELVGEKPPLYPARYAHGLFFALLSRVSPELAQKLHEAPRKPFT
LAPLPGPEGATLKGTLRLRLTTLDDGLFAPFLRALLEAAPDGLPLGDSSY
RLARVLATREGHPLAGATSWEELKEAPKREKATFRFLTPTVFATSKPGGR
TRYTPLPDPRLIAGSLLDKWQAHSPFPYNPKEEAALRELFELDLEVAGFR
NLRFHRVQAGKGFFPGFTGEATLRLWSQSLEAQEALGRLHALAFFSGVGA
KTPYGMGLAVPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4c9d Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H23 H42 P45 K47 A145 T146 S147 K148 P149 T153 Y155 R162 L163 S167 R208 K213 G251 A252 K253 Y256
Binding residue
(residue number reindexed from 1)		H23 H42 P45 K47 A143 T144 S145 K146 P147 T151 Y153 R160 L161 S165 R206 K211 G249 A250 K251 Y254
Binding affinityPDBbind-CN: Kd=3.9nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4c9d, PDBe:4c9d, PDBj:4c9d
PDBsum4c9d
PubMed24150936
UniProtQ53VU8

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