Structure of PDB 4c7o Chain A Binding Site BS01

Receptor Information
>4c7o Chain A (length=293) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFIN
RVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVV
LMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAE
QVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMD
EIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGD
ARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILG
Ligand information
>4c7o Chain E (length=48) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uguugguucucccgcaacgcggaagcgugugccgggauguagcuggca
<<<<<<<<.<<<<<<<<<<<....>>>>.>>>.>>>>...>>>>>>>>
Receptor-Ligand Complex Structure
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PDB4c7o The Structural Basis of Ftsy Recruitment and Gtpase Activation by Srp RNA
Resolution2.6 Å
Binding residue
(original residue number in PDB)		E277 K278
Binding residue
(residue number reindexed from 1)		E274 K275
Binding affinityPDBbind-CN: Kd~0.5uM
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Cellular Component
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c7o, PDBe:4c7o, PDBj:4c7o
PDBsum4c7o
PubMed24211265
UniProtP0AGD7|SRP54_ECOLI Signal recognition particle protein (Gene Name=ffh)

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