Structure of PDB 4c7b Chain A Binding Site BS01

Receptor Information
>4c7b Chain A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRQYDLPYPEAIFEL
PFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDG
LERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPV
CTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTE
AVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEE
MRDLVQRETGK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4c7b Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		F180 V292 F294 G295 E296 P297 L298
Binding residue
(residue number reindexed from 1)		F48 V160 F162 G163 E164 P165 L166
Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 F157 R158 N229 D231 H248
Catalytic site (residue number reindexed from 1) P34 D35 F36 R37 N97 D99 H116
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4c7b, PDBe:4c7b, PDBj:4c7b
PDBsum4c7b
PubMed24211137
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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