Structure of PDB 4c37 Chain A Binding Site BS01
Receptor Information
>4c37 Chain A (length=338) Species:
9913
(Bos taurus) [
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ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSYGRVMLVKH
METGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKD
NSNLYMVLEYLPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL
IYRDLKPENLMIDQQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS
KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS
SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA
PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Ligand information
>4c37 Chain I (length=20) Species:
9913
(Bos taurus) [
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TTYADFIASGRTGRRNAIHD
Receptor-Ligand Complex Structure
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PDB
4c37
The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
S53 E127 F129 R133 E170 L198 G200 P202 E203 E230 Y235 P236 F239 D241 I246
Binding residue
(residue number reindexed from 1)
S41 E115 F117 R121 E158 L186 G188 P190 E191 E218 Y223 P224 F227 D229 I234
Enzymatic activity
Catalytic site (original residue number in PDB)
D166 K168 E170 N171 D184 T201
Catalytic site (residue number reindexed from 1)
D154 K156 E158 N159 D172 T189
Enzyme Commision number
2.7.11.11
: cAMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004679
AMP-activated protein kinase activity
GO:0004691
cAMP-dependent protein kinase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0019904
protein domain specific binding
GO:0034237
protein kinase A regulatory subunit binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0001707
mesoderm formation
GO:0006468
protein phosphorylation
GO:0010737
protein kinase A signaling
GO:0016310
phosphorylation
GO:0018105
peptidyl-serine phosphorylation
GO:0034605
cellular response to heat
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0001669
acrosomal vesicle
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0005952
cAMP-dependent protein kinase complex
GO:0031594
neuromuscular junction
GO:0036126
sperm flagellum
GO:0048471
perinuclear region of cytoplasm
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:4c37
,
PDBe:4c37
,
PDBj:4c37
PDBsum
4c37
PubMed
24072592
UniProt
P00517
|KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha (Gene Name=PRKACA)
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