Structure of PDB 4c30 Chain A Binding Site BS01

Receptor Information

>4c30 Chain A (length=631) Species: 1299 (Deinococcus radiodurans)

PDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHYGVH
PGEILAVTFTNKAAAEMRERAGHLVPGAGDLWMSTFHSAGVRILRTYGEH
IGLRRGFVIYDDDDQLDIIKEVMGSIPGIGAETQPRVIRGIIDRAKSNLW
TPDDLDRSREPPRDAAAEAYRRYEVRKKGQNAIDFGDLITETVRLFKEVP
GVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVGDPDQSIY
KFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLIENNTERL
DKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAWSEMAILY
RTNAQSRVIEESLRRVQIPARIVGGVGFYDRREIRDILAYARLALNPADD
VALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAHKATEFAGLM
EAMSEAADNYEPAAFLRFVMETSGYLDLLRQEGQEGQVRLENLEELVSAA
EEWSQDEAIADFLDDAALLSSVDDMRTKAEPEDAVTLMTLHNAKGLEFPV
VFIVGVEQGLLPSKGAIAEGPSGIEEERRLFYVGITRAMERLLMTAAQNR
MQFGKTNAAEDSAFLEDIEGLFDTVDPYGQP

Ligand information

>4c30 Chain X (length=23)

gcagtgctcgcaggtcgtttttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4c30 Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): R142 Y261 F263 R362 N364 R422 G424 I425 G426 T428 L544 S546 S547 T569 H571 S593 F633
• Binding residue (residue number reindexed from 1): R136 Y250 F252 R351 N353 R411 G413 I414 G415 T417 L518 S520 S521 T539 H541 S563 F603

Enzymatic activity

• Catalytic site (original residue number in PDB): K38 T39 D227 E228 Q258 R617
• Catalytic site (residue number reindexed from 1): K32 T33 D216 E217 Q247 R587
• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:4c30, PDBe:4c30, PDBj:4c30
• PDBsum: 4c30
• PubMed: 24143224
• UniProt: Q9RTI9